Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form
Polymer-based electrospun amorphous solid dispersions (ASDs) were prepared and investigated from pharmaceutical application point of view.Spironolactone Coaster (SPIR) was used as model drug mixed in various concentrations with polymers suitable for fibre formation, such as vinylpyrrolidone-vinyl acetate copolymer, polyvinylpyrrolidone K30 and hydr